Smoking cannabis has different effects on the body. Researchers have now investigated whether there is also a risk of thrombosis.
Cannabis: what happens in the body?
As the University of Saarbrücken announced, the scientists compared the blood cells of three marijuana smokers with those of three non-smokers. All test subjects are in their mid-30s. Prof. Kaestner and his team observed that the red blood cells swelled immediately after contact with the cannabis active ingredient dronabinol – more so in people who regularly smoked marijuana than in non-users.
Dronabinol – also known as tetrahydrocannabinol (THC) – stimulates a specific ion channel on red blood cells during smoking. The channel called TRPV2 regulates the uptake and release of certain messenger substances into and out of the cell. Cannabis consumption increases the concentration of sodium ions in the blood cells, which means that more water is absorbed. This causes the cell to swell.
However, the situation does not last long. Within an hour, the cells returned to their original shape. According to Prof. Kaestner, however, the risk of thrombosis for cannabis smokers increases slightly during this time. Because the blood cells are larger and rounder, they tend to get stuck in small capillaries. In addition, when smoking cannabis, the vessels constrict, which also increases the risk of micro-thrombosis.
Scientists: health risk is unclear
According to the German Society for Angiology (DGA), in the event of a thrombosis, vessels such as veins are blocked by a blood clot. Leg and pelvic veins in particular can be affected. If a clot forms in these areas, there is a risk of the clot being carried through the bloodstream to the lungs. A pulmonary embolism is imminent. Various factors can lead to thrombosis. One danger is, for example, prolonged lying down, for example during a hospital stay. In this case, thrombosis stockings prevent vascular occlusion. However, the tendency to thrombosis can also be inherited.
The disease can be fatal. According to figures from the DGA, around 100,000 people die every year in Germany as a result of a pulmonary embolism. This is the third most common fatal cardiovascular disease after heart attack and stroke. If thrombosis is suspected, action must be taken quickly. As a first step, the patient is injected with an anticoagulant substance. This prevents the clot from growing and leading to a pulmonary embolism.
Prof. Kaestner cannot say that the observations of the Saarbrücken researchers actually pose an immediate health risk. This question was not part of the study.
